Evaluation and improvement of Streptococcus suis bacterins - Ontario Pork - Active Research
Friday, July 3, 2020
    

Active Research

Ontario Pork has a call for research proposals once a year. These projects were approved for funding by the board on recommendation of the research committee. If you have questions or need further information about the research posted here please contact Cristiane Mesquita at cristiane.mesquita@ontariopork.on.ca.


Active Research

Evaluation and improvement of Streptococcus suis bacterins

Evaluation and improvement of Streptococcus suis bacterins

Project 19-006 - Researchers: Dr. Mariela Segura and Dr. Marcelo Gottschalk, University of Montreal

Streptococcus suis disease management is difficult due to a lack of proven effective vaccines. Currently, field immunization efforts focus on bacterins (autogenous vaccines) that have contradictory results reported.  There is lack of a standardized protocol for autogenous vaccine formulation and, more importantly, of scientific evaluation of the effect of formulation on vaccine efficacy. Adjuvants are key components in vaccine preparations and can dramatically influence the immune response to the vaccine antigen(s). However, the effect an adjuvant may have on the protective capacity of a S. suis bacterin has never been scientifically evaluated. We propose to study and compare the immune response and protection generated by an autogenous vaccine formulated with different adjuvants under controlled conditions using experimental challenge of piglets.  An improved vaccine strategy will have an impact on swine health and welfare, employee health and safety (zoonosis) and environmental and economic sustainability (reduction of pathogens and antimicrobial use). 

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